Answer:
Option A
Explanation:
During the colonial era where Europeans started settling and colonizing all over the country brought many germs with them that they were immune too. Because of that fact "New world diseases" or option A such as: chicken pox, the flu, and malaria sweeping through the country at a alarming rate killing at least 90% of Native Americans in the country.
Hope this helps.
The answer is most likely c.
The answers are economic, Political, and natural disasters
If you're referring to the Civil War era, in the years leading up to the war, once such compromise could have been that slavery could continue to exist where it was, but not spread to other states.