Okay so I have wrote down the answer for u and please don't mind my handwriting , I was just in a hurry
The answer is...
B. Buffers
True, if you are 50 and time your age by BMR
New medications have more strict process to receive an approval from FDA compared to new dietary supplements which, some doesn't even need FDA's approval to be released in the market. Dietary supplements include in their labels "No approved therapeutic claims" to save them from legal responsibilities. During the titration, the repeated trials for the supplement varies from the medication is maybe because of less stability preservation of the supplement which caused it to degrade.