Answer:
Explanation:
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Answer:
Equilibrium between bound and unbound state is necessary for proper drug function, depending on the target areas of the drug therapy.
Explanation:
Plasma protein binding is the degree to which medical drugs are attached to the blood protein, which in most cases is albumin. the efficacy of drug therapy is affected by the extent to which the drug is either bound or unbound to proteins in the bloodstream.
<u>Role of bound state:</u> Unbound drugs dissociate from the bloodstrream and can easily transverse the cell membranes or be diffused, which translates to absorption by the liver and other tissues and directly increases the rate of drug metabolism requirement. Hence the bound state keeps these drugs in the blood and body for a longer period of time.
Consequently, anti-infective drugs targeting the liver and other tissues, must be able to diffuse through capillary membranes to reach its target outside the plasma to the infection site typically located outside plasma.
Subsequently, <em>the law of mass action dictates that the binding of drugs to plasma proteins is reversible, and equilibrium between the protein-bound and unbound drug is quickly established.</em>
The group that is not changed in an experiment is the control group, or control.
