The Ras Proto-Oncogene is a gene found in normal cells, which by the single point mutation mentioned in the question, can turn into Oncogene. Because Proto-Oncogene is a gene that controls and regulates the division of the cell, a mutation in this gene leads to uncontrolled cell divisions which then leads to cancer. The correct answer is D since RAF-Activation describes "Rapidly Accelerated Fibrosarcoma, fibrosarcoma being a cancer which affects fibrobalst cells.
Because your final periods can be irregular, menopause is confirmed 12 months after your last period. It is not normal to bleed or spot 12 months or more after your last period. Bleeding after menopause is usually a sign of a minor health problem but can sometimes be an early sign of more serious disease.