The reason why manuscripts were so expensive in the early fifteenth century is because the printing press wasn't invented until 1440, meaning that every individual script had to be written by hand.
I dont have an answer to this it would take to long to write, sorry.
I think philosophy, science, and communication
In sum, Stowe's Uncle Tom's Cabin widened the chasm between the North and the South, greatly strengthened Northern abolitionism, and weakened British sympathy for the Southern cause. The most influential novel ever written by an American, it was one of the contributing causes of the Civil War.