Answer:
4. The suspected causative agent must be isolated from the diseased host and grown in pure culture
Explanation:
Robert Koch (1843-1910) was one of the most important bacteriologists of all time. Famous for discovering the tuberculosis bacillus (precisely on March 24, such as today, in 1882), he also discovered the cholera bacillus and is considered the founder of bacteriology. He worked on the isolation of infectious agents and reinfections from pure cultures, experiences from which he established the "Koch Postulates".
These postulates have been taken as a reference that describes the etiology of all the causative agents of an infectious disease, although they were originally used to describe only the tuberculosis bacillus. They are the following:
1- The agent must be present in each case of the disease and absent in the healthy.
2- The agent should not appear in other diseases.
3- The agent must be isolated in a pure culture from the lesions of the disease.
4- The agent has to cause the disease in an animal that can be inoculated
Answer:
Hepato- and nephrotoxicity of fluoride have been demonstrated in animals, but few studies have examined potential effects in humans. This population-based study examines the relationship between chronic low-level fluoride exposure and kidney and liver function among United States (U.S.) adolescents. This study aimed to evaluate whether greater fluoride exposure is associated with altered kidney and liver parameters among U.S. youth.
This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (2013–2016). We analyzed data from 1983 and 1742 adolescents who had plasma and water fluoride measures respectively and did not have kidney disease. Fluoride was measured in plasma and household tap water. Kidney parameters included estimated glomerular filtration rate (calculated by the original Schwartz formula), serum uric acid, and the urinary albumin to creatinine ratio. Liver parameters were assessed in serum and included alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, blood urea nitrogen, gamma-glutamyl transferase, and albumin. Survey-weighted linear regression examined relationships between fluoride exposure and kidney and liver parameters after covariate adjustment. A Holm-Bonferroni correction accounted for multiple comparisons.
The average age of adolescents was 15.4 years. Median water and plasma fluoride concentrations were 0.48 mg/L and 0.33 μmol/L respectively. A 1 μmol/L increase in plasma fluoride was associated with a 10.36 mL/min/1.73 m2 lower estimated glomerular filtration rate (95% CI: −17.50, −3.22; p = 0.05), a 0.29 mg/dL higher serum uric acid concentration (95% CI: 0.09, 0.50; p = 0.05), and a 1.29 mg/dL lower blood urea nitrogen concentration (95%CI: −1.87, −0.70; p < 0.001). A 1 mg/L increase in water fluoride was associated with a 0.93 mg/dL lower blood urea nitrogen concentration (95% CI: −1.44, −0.42; p = 0.007).
Fluoride exposure may contribute to complex changes in kidney and liver related parameters among U.S. adolescents. As the study is cross-sectional, reverse causality cannot be ruled out; therefore, altered kidney and/or liver function may impact bodily fluoride absorption and metabolic processes.
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Answer:
The correct answer is
Explanation:
Lobster is the answer. People eat lobster in pieces which we call as lobster piece.
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<h2>
Answer:A</h2><h2>All life on Earth stores its genetic material inside the nuclei of its cells. </h2>
All life on Earth has DNA. All life on Earth has the same set of mutations in its genes
A scientist who studies living things is called a biologist
