The same, unknown bacteria is isolated from 20 sick individuals. Their samples were grown in culture and then placed in 10 healt
hy mice. Those mice started to show signs of a heightened immune response. To determine if the bacteria is pathogenic, what is the next step by using Koch’s postulates?
The next step should be isolate the microorganism from the mice and check if it is identical to the original microbe.
According to Koch's postulates, a microbe can be considered as a causative agent of a disease only after all the following are established:
The microorganism should be present in all the organism suffering from the disease.
The isolated microorganism should be grown in pure culture.
The organism grown in the culture should be reintroduced in the susceptible but healthy host.
Finally the microorganism must be re-isolated from the experimental host an cultured to see whether it is identical to the original specific microorganism.
