In the disease leukocyte adhesion deficiency, leukocytes cannot stop rolling at the site of a wound. Normally leukocytes are signaled through a ___________ pathway to activate ___________ to induce tight binding and eventually migration out of the vein.
A. GPCR; integrins
B. RTK; selectin
C. GPCR; ICAM
D. RTK; cytokine
E. GPCR; endothelial adhesion molecule
Answer:
A. GPCR; integrins
Explanation:
GPCRs stands for G protein-coupled receptors and play important roles in inflammation.
Inflammation is a terminology in medicine that describes the condition of any part of the body, consisting of congestion of the blood vessels, with obstruction of the blood current, and growth of morbid tissue. It is manifested outwardly by redness and swelling, attended with heat and pain
Inflammatory cells like polymorphonuclear leukocytes (PMN), monocytes and macrophages is characterised by a large number of GPCRs for classic chemoattractants and chemokines.
An intergrins is any of many heterodimeric transmembrane proteins that function as receptors in communication between cells.
