Nicaragua, along with Costa Rica, El Salvador, Guatemala, Honduras, and the Dominican Republic, signed the Central America – Dominican Republic – United States Free Trade Agreement (CAFTA-DR) in August 2004. The agreement entered into force for Nicaragua and the United States on April 1, 2006. In 2010, Central American countries, including Nicaragua, signed a trade agreement with the European Union. In 2014, a partial free trade agreement came into effect between Nicaragua and Cuba. Additionally, Nicaragua has trade agreements with Mexico, Panama, Taiwan, Chile, and the Dominican Republic.
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The seventeenth century saw the end of the great epidemics of hunger that had periodically threatened the European population in the preceding centuries, and the nineteenth century signified a revolutionary change in medicine - sepsis, vaccines, anesthesia, etc. - whose social applications - hygiene , compulsory vaccination, etc. - determined a rapid drop in the mortality rate, especially infant mortality. The joint action of both factors caused a revolutionary change in the demographic structure of the old continent. The decrease in mortality in the first years decisively increased the percentage of the population reaching reproductive age, and the reduction in that of adults favored the prolongation of the half-life, with the consequent aging of the populations.
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