The Trail of Tears is the name of the forced Indian migration from areas east of the Mississippi River to areas in Oklahoma. This was part of Andrew Jackson's Indian Removal Policy.
There were many such things, for example, systematic racism. African-Americans were still living in poverty or didn't have civil rights and segregation was strong. They could only join white communities if they were musicians or things like that where they would have to play for white guests of parlors. It wasn't until the 60s that the African-American people were given their civil rights.
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That cultural, political,scientific and intellectual explosion in Europe between the 14th and 17th centuries.