Answer:
E1: Pyruvate dehydrogenase, TPP, oxidative decarboxylation reaction
E2: Dihydrolipoyl transacetylase, Lipoamide and Co-enzyme A, transacetylation reaction.
E3: Dihydrolipoyl dehydrogenase, FAD and NAD+, oxidation reaction
Explanation:
Pyruvate dehydrogenase is a multi-enzyme complex with 5 co-enzymes and 3 apo-enzymes:
Pyruvate dehydrogenase (E1) , which uses thiamine pyrophosphate (TPP) as as co-enzymes to catalyze oxidative decarboxylation of pyruvate to hydroxyethyl-TPP.
Dihydrolipoyl transacetylase (E2): which uses lipoamide and coenzyme A as co-enzymes to catalyse the transacetylation from TPP to Lipoamide to form acetyl lipoamide.
Dihydrolipoyl dehydrogenase (E3) which uses FAD and NAD+ as co-enzymes to catalyze the oxidation of lipoamide
C consider the impact of their actions hope this helps:)
