Question

Is glycogen phosphorylase activated, inhibited, or unaffected in response to an insulin signal in skeletal muscle?

Answer 1

Options:A) activated B) inhibited C) unaffected.

Answer: B. Inhibited.

Explanation:Glycogen phosphorylase is an essential and necessary Enzyme in the Glycolytic partway,it is the Glycogen phosphorylase that acts on the reaction at the initiation of glycogen degradation.

Glycogen phosphorylase have different roles in the Glycolytic partway as in some cases it is activated in another it is inhibited, Glycogen phosphorylase is being studied as a model protein that is controlled by both reversible phosphorylation and allosteric effects(The binding of a ligand to one site on a protein molecule so that the characteristics of another site on the same protein are affected)

Glycogen phosphorylase is inhibited.in response to insulin signal in the muscles.

Answer 2

Answer: Glycogen phosphorylase is inhibited in response to an insulin signal in skeletal muscle.

Explanation:During insulin signal in skeletal muscle,the insulin receptor is received by tyrosine kinase following an oxidative reaction. Then it acts as an enzyme that shifts phosphate groups from the nucleotide,Adenosine Triphosphate to tyrosine residues on intracellular target proteins.

Insulin is binded to the alpha subunits causing the beta subunits to form phosphorylase unaided.this is known as autophosphorylation,

catalytic activity of the receptor is then activated.

The receptor activates and form phosphorylase with couple of intracellular proteins, which therefore alters their activity, thus generating a biological response.