A traumatic experience, brain damage , genetics and stress, i hope these help I'm not so sure they're the major causes but its some of the ones I've read.
The biopsychosocial (BPS) model consolidates connections between organic, mental, and social components to help decide why an individual may experience the ill effects of a confusion. Clinicians and specialists in different fields use it to finding and treat patients.
This model mirrors the advancement of sickness through the mind boggling connection of natural components (hereditary, biochemical, and so forth.), mental variables (disposition, character, conduct, and so forth.) and social elements (social, familial, financial, restorative, and so on).