Answer:
A presynaptic neuron knows when and how much of a certain neurotransmitter it has to release into the synapse by the frequency of the action potential.
Explanation:
Two nuerons connect to each other through synapse. When an action potential, or nerve impulse, arrives at the axon terminal, it activates voltage-gated calcium channels in the cell membrane, then the calcium which is present in hi highconcentration outside the neuron than inside, rushes into the cell. The Calcium then allows synaptic vesicles to fuse with the axon terminal membrane, releasing neurotransmitter into the synaptic cleft.
The nuerotransmitter than binds to the receptors at the post-synaptic cleft and causes the opening or closing of the channels, hence, depolarizing or hyperpolarizing the cells.This can produce a change in the membrane potential—voltage across the membrane of the receiving cell.
