Answer:
Endosteum plays an important role in bone repair, bone remodelling and appositional bone growth.
Explanation:
Endosteum consists of a soft and thin connective tissue that lines the cavity of femur and humerus. Some of the major functions of endosteum are as follows:
Bone remodelling: Endosteum can stimulate the bone resorption that leads to the formation of new bone from the outside.
Bone repair: Hematoma, at the time of bone injury causes the division of endosteal cells and helps in bone repair.
Appositional bone growth: Endosteum that line the osteoblast cell can secrete bone matrix and increases the bone diameter.
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For example, pH can have an effect of the state of ionization of acidic or basic amino acids. Acidic amino acids have carboxyl functional groups in their side chains. Basic amino acids have amine functional groups in their side chains. If the state of ionization of amino acids in a protein is altered then the ionic bonds that help to determine the 3-D shape of the protein can be altered. This can lead to altered protein recognition or an enzyme might become inactive.
Changes in pH may not only affect the shape of an enzyme but it may also change the shape or charge properties of the substrate so that either the substrate connot bind to the active site or it cannot undergo catalysis.
In geneal enzyme have a pH optimum. However the optimum is not the same for each enzyme.
