To combat the threat of tropical diseases such as malaria and yellow fever, the United States decided to use new measures to eradicate the disease before the construction of the Panama Canal. Under the leadership of Colonel William Crawford Gorgas, many changes were made. When it was discovered that mosquitoes were the source of the disease, Gorgas who was appointed as the head of hospital and sanitation, he made sure that containers with stagnant water were removed because mosquitoes lay their eggs there. He also built domestic water systems to eliminate the need to collect rain water. Prophylactic Quinine was supplied to the people in the area and fumigation and oiling of streams were launched. Those who were sick were quarantined and workers would sleep in screened structures so that mosquitoes would not be able to bite them. These programs resulted in the successful elimination of tropical diseases in the area and the health of workers improved.
The addition of Bill of Rights made Virginia and New York finally agree to ratify the constitution. Originally, there were 13 states that needed to ratify the constitution. Hope this answer helps.
The completion of the Transcontinental Railroad greatly affected companies that made products in that it made it far easier for them to transport their goods over long distances to markets, which greatly increased profits and output.
