If you are talking about the development of political parties, then the issue that led it to them was “the struggle over ratification of the federal Constitution of 1787” (loc.gov).
Federalists, such as Alexander Hamilton, wanted a strong, central government and the Anti-Federalists, like Thomas Jefferson, “advocated states’ rights instead of centralized power”. (Library of Congress)
Its true ! Because what I'm thinking is its the basis of Democracy .
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The secession of South Carolina and forming of the Confederates all happened after Abraham Lincoln became president and bloody Kansas happened before Lincoln was elected.
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The Byzantine Empire was the eastern continuation of the Roman Empire after the Western Roman Empire's fall in the fifth century CE. It lasted from the fall of the Roman Empire until the Ottoman conquest in 1453.