People with sickle cell anemia have one incorrect amino acid in their beta chain. The first seven amino acids in the beta chain

Question

3 years ago

15

for hemoglobin A (normal) and hemoglobin S (sickle cell) are listed below. Which amino acid is different in hemoglobin S?

1 answer:

denis-greek [22] · Answer 1 · 2022-03-02T09:34:13+03:00

Answer: Valine

Explanation:

hemoglobin A (normal) is HbA, while hemoglobin S (present in people with sickle cell anemia) is HbS

A sequence of 146 amino acids is present in the Hemoglobin.

The first 6 amino acids in HbA are: valine, histidine, leucine, threonine, proline, and glutamic acid.

The first six amino acids in HbS is:

valine, histidine, leucine, threonine, proline, and VALINE

In Hbs, the 6th amino acid (Glutamic acid) has already been mutated to Valine, a nonpolar, branched amino acid.