Answer:
The correct insulin pathway is described as under:
2. Binding of insulin to the alpha subunit of the insulin receptor
8. Activation of insulin receptor tyrosine kinase
3. Phosphorylation of IRS proteins
6. Phosphorylation of phosphinositide 3-kinase (PI-3K)
4. Conversion of PIP2 to PIP3
7. Activation of PIP3-dependent protein kinase B (PDK1)
5. Glut4 receptors transported to the cell membrane
Explanation:
The insulin signaling pathway is described as under:
RTK (receptor tyrosine kinases) which is a receptor for insulin is an extracellular receptor but in contrast to other cell surface receptors it is catalytic in nature. In the absence of insulin (ligand), it is monomeric but as soon as it gets activated (activation occurs upon ligand binding), it undergo dimerization. It leads to auto-phosphorylation in it's tyrosine residue which subsequently leads to phosphorylation of tyrosine residue of other receptors. Such hyper-phosphorylated receptor have high affinity with enzyme/molecule like IRS protein which have SH2 domain . IRS down stream activates phosphinositide 3-kinase (PI-3K). This enzyme converts component of animal cell membrane PIP2 into PIP3. PIP3 also remains membrane bound but it has the potential to phosphorylate another enzyme named as PIP3-dependent protein kinase B (PDK1). Further, PDK1 leads to the activation of Akt or PK-B. Akt is a serine-threonine kinase which ultimately leads to the recruitment of Glut4 receptors on cell membrane for uptake of more and more glucose into the cell.
Note: Apart from this Akt also phosphorylates another protein named as FOXO which ultimately causes cell growth, Akt can also phosphorylate BAD protein so as to restrict cell apoptosis or we can say it leads to cell survival, Akt also leads to translation in a cell with the help of mTOR raptor etc.
Answer:
A.
Explanation:
in DNA, G matches with C and A matches with T. G cannot match with G, A cannot match with A, etc.
Answer:
Ammonia feels slippery or soapy to the touch because<u> it is an [alkaline] base and can dissolve some of the fats and oils in your skin.</u>
Explanation:
The concept <em>alkali</em> refers to salts that contain alkali and alkaline earth metal elements. According to chemists, all alkaline solutions are <u>basic</u>.
Ammonia is an alkaline solution that, when combined with water, it actually makes soap. This base feels slippery to the touch because when it makes contact with all the oils that are naturally present in your skin, it produces soap, making it slippery and soapy.
A carnivore is something that eat meats.
The question to the above information is;
What is the best use of an atomic model to explain the charge of the particles in Thomson's beams?
Answer;
An atom's smaller negative particles are at a distance from the central positive particles, so the negative particles are easier to remove.
Explanation;
-Atoms are comprised of a nucleus consisting of protons (red) and neutrons (blue). The number of orbiting electrons is the same as the number of protons and is termed the "atomic number" of the element.
J.J. Thomson discovered the electron. Atoms are neutral overall, therefore in Thomson’s ‘plum pudding model’:
- atoms are spheres of positive charge
- electrons are dotted around inside
