need larger doses to feel the same level of intoxication
Answer : b
Answer: Question 1 answer: Skin cells continually replicate
Explanation: The cells in the superficial or upper layers of skin, known as the epidermis, are constantly replacing themselves. This process of renewal is basically exfoliation (shedding) of the epidermis. But the deeper layers of skin, called the dermis, do not go through this cellular turnover and so do not replace themselves.
Question 2 answer: Heart cells undergo terminal differentiation
Explanation: Different cell types (e.g., neurons, skeletal and heart myocytes, adipocytes, keratinocytes) undergo terminal differentiation, in which acquisition of specialized functions entails definitive withdrawal from the cell cycle.
Question 3 answer: DNA replicates in the nucleus
Explanation: DNA replication occurs in the cytoplasm of prokaryotes and in the nucleus of eukaryotes. Regardless of where DNA replication occurs, the basic process is the same. The structure of DNA lends itself easily to DNA replication.
Question 4 answer: The ability to reverse terminal differentiation might affect gene expression in a complex organism
Question 5 answer Cytoplasm replicates during mitosis
Explanation: This process involves replication of the cell's chromosomes, segregation of the copied DNA, and splitting of the parent cell's cytoplasm. ... The outcome of binary fission is two new cells that are identical to the original cell.
Answer:
In one way, the existence of a nonsense mutation would lead to the generation of a premature termination codon that will be identified by the RNA polymerase as a termination sequence encouraged by the activity of Rho factor to dissociate ribosome, thus, discharging RNA polymerase and preventing further transcription mechanism making the transcription of the downstream sequence impossible.
For the second way, there is a need to consider that the mechanism is taking place post-transcriptionally. Thus, the effects should be devised after transcription has taken place and the only fate lies in the mechanism encouraged by the RNA dependent RNA-polymerase. However, for this to take place, the event of genetic recombination can also be taken into account leading to the appearance of the faulty gene in the sequence. Apart from this, the open reading frame is required to be co-expressive that would be the most suitable factor, which determines whether the downstream sequences will be transcribed or not post nonsense mutation.
However, the total change relies upon the fact that the mutation is taking place artificially or is induced naturally. One more thing to consider is that there is an existence of another gene known as MCB 354, which is encrypted by another gene and is probably monitored by another promoter sequence. Thus, co-expression would probably be the mechanism in terms of the rho-dependent termination.