Answer:
1. The difference between the normal hemoglobin protein DNA sequence and the sickle cell hemoglobin DNA sequence is a base to base shift, in this case adenine (GAG) to thymine (GTG).
2. The difference affects the amino acid sequence of the protein by replacing glutamic acid (Glu) with valine (Val).
Explanation:
In sickle cell anemia, a change in the DNA nucleotide sequence is observed, where adenine is substituted by thymine, whose expression is the change in the amino acid sequence of globine β, incorporating valine instead of glutamic acid. This represents a molecular mutation - point mutation - by subtitution, which corresponds to missense mutation.
<u>Normal hemoglobin protein in a RBC</u>
DNA CTG ACT CCT GAG GAG AAG TCT
Amino acids Leu Thr Pro Glu Glu Lys Ser
<u>Sickle cell hemoglobin protein in a RBC</u>
DNA CTG ACT CCT <em>GTG</em> GAG AAG TCT
Amino acids Leu Thr Pro <em>Val</em> Glu Lys Ser
When GAG is transcribed to mRNA, the CUC codon is obtained, which codes for glutamic acid. Thymine substitution causes the DNA sequence to change to GTG, which is transcribed as CAC, the codon that encodes the amino acid valine. The <u>change from glutamic acid to valine in β-globin causes an altered hemoglobin, giving the abnormal erythrocytes observed in sickle cell disease</u>.
Answer:it causes when liquid or oil gets warm and rises.
When sun heats the gases it causes them to rise.
Explanation:
The excessive force of the blood that is being pumped within the blood vessels cause hypertension. This disease is often associated with an inactive lifestyle, poor diet, and genetics. First aid for hypertension includes putting a cold pack at the nape while elevating the leg higher than the level of the heart.
Balamuthia mandrillaris is an amoeba that was discovered in 1986 in the brain of the baboon that dies in San Diego Wild Animal Park. This can be found in the soil and water, therefore it is freely living. It is known to cause the neurological condition known as granulomatous amoebic encephalitis. In a study published by National Center for Biotechnology Information, it has a case fatality rate of >98%. Majority of this case can be found in warmer regions that affects individuals mostly of Hispanic origin. Documented cases had been reported from the Latin Americas in significant number, followed by the United States, Asian regions and some in Europe. However, a specific number of cases worldwide may never be known due to the following factors: lack of awareness, poor diagnosis and a poor public health system.
It is still yet to be known if its a serious public health concern worldwide.
