The earliest written use of the name, spelled Rontaks, was in 1724 by the French missionary Joseph-François Lafitau. He defined it as tree eaters. In the Mohawk language, Adirondack means porcupine, an animal that may eat bark. The Mohawks had no written language at the time so Europeans have used various phonetic spellings. An English map from 1761 labels it simply Deer Hunting Country and the mountains were named Adirondacks in 1837 by Ebenezer Emmons.
C. often because t<span>here are three major types of </span>plate<span> boundaries. If </span>two<span> tectonic </span>plates<span> collide, they form a convergent </span>plate<span> boundary. Usually, one of the converging </span>plates<span> will move beneath the other, which is known as subduction. Deep trenches are often formed where tectonic </span>plates<span> are being subducted and earthquakes are common</span>
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
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<span> Purple loosestrife is a very hardy perennial which can rapidly degrade wetlands, diminishing their value for wildlife habitat. Wetlands are the most biologically diverse, productive component of our ecosystem. Hundreds of species of plants, birds, mammals, reptiles, insects, fish and amphibians rely on healthy wetland habitat for their survival.</span>
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Meiosis | Ploidy | Life Cycles | Phases of Meiosis | Prophase I | Metaphase I ... (for example, one diploid 2n cell producing two diploid 2n cells; one haploid n cell producing ... is sporophyte, while pollen and ovaries contain the male and female ...
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