In the Battle of Waterloo in 1815.
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California would enter as a Free state. The Missouri Compromise line would be enforced. A new fugitive slave law would be enacted. The Federal government would assume debt of Texas.
The Romans were initially interested in expansion via Sicily (which at that time was a cultural melting pot), part of which lay under Carthaginian control. At the start of the first Punic War, Carthage was the dominant power of the Western Mediterranean, with an extensive maritime empire.
Spain had three objectives in its policy toward the Philippines, its only colony in Asia: to acquire a share in the spice trade, to develop contacts with China and Japan in order to further Christian missionary efforts there, and to convert the Filipinos to Christianity. Only the third objective was eventually realized, and this not completely because of the active resistance of both the Muslims in the south and the Igorot, the upland tribal peoples in the north. Philip II explicitly ordered that pacification of the Philippines be bloodless, to avoid a repetition of Spain's sanguinary conquests in the Americas. Occupation of the islands was accomplished with relatively little bloodshed, partly because most of the population (except the Muslims) offered little armed resistance initially.
Answer:
Among the different kinds of parasites, bacteria and viruses, and their associated diseases, that were transmitted along the Silk Roads, plague was one of the most notable. Plague is a disease caused by the bacteria Yersinia pestis, commonly carried by fleas.
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