When the immune system attacks itself.
Answer:
It develops when the immune system overreacts to a drug, dust, and ect.
Answer: When people become addicted to any form of drug you'll often spot mood swings and mental health issues. Fidgeting is common amongst some.
I am pretty sure that the answer on the first question is poverty, because most rural areas are not as developed as towns.
The second one best matches with physical health, because the physical state has the strongest positions in lige of every alive being.
The next one is the option ''doubled''.