Answer: Phagocyte receptors that detect PAMPs
Explanation:
TLRs or Toll-like receptors, are a family of proteins that are part of the innate immune system. TLRs are transmembranous and recognize pathogen-associated molecular patterns (PAMPs), which are groups of chemical characteristics common to certain types of pathogens. Patterns detected by TLRs include lipopolysaccharide, a compound found on the surfaces of Gram-negative bacteria, and double-stranded RNA, which is an integral part of the life cycles of many viruses. These PAMPs are generally important for the survival of the pathogen, so they are well preserved. <u>Activation of these receptors induces inflammatory responses in leukocytes of myeloid lineage, signaling via NF-κB, which is a transcription factor that activates pro-inflammatory genes</u>. Activated TLRs also increase the production of co-stimulatory molecules such as CD80, CD86 and CD40. These proteins, expressed on the surface of antigen-presenting cells, are necessary for the activation of T-lymphocytes by dentritic cells and macrophages already showing antigens in their MHC type II molecules (Major Histocompatibility Complex, they participate in the presentation of antigens to T lymphocytes)
<u>In addition, TLR-mediated signaling on antigen-presenting cells (APCs) plays an important role in linking the innate and adaptive immune responses</u>.
<span>The appropriate response is the promoter. It is perceived by RNA polymerase and a related sigma figure, which thus are frequently conveyed to the promoter DNA by an activator protein's authoritative to its own DNA-restricting site close-by.</span>
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