Answer:
The uncompetitive and mixed inhibitors are not affected by the substrate concentration while inhibition by a competitive inhibitor can be overcome by increasing the concentration of the substrate.
Explanation:
A competitive inhibitor competes with the substrate for the active site of the enzyme. When the competitive inhibitor combines with the enzyme and forms the enzyme-inhibitor complex (EI complex), the substrate cannot bind to the active site. However, the inhibition by competitive inhibitor can be overcome by increasing the substrate concentration around the enzyme which in turn would allow the substrate to bind to the active site and the reaction would proceed.
On the other hand, an uncompetitive inhibitor binds to the site at the enzyme different from the active site. Once the ES complex is formed, the uncompetitive inhibitor joins the complex to inhibit the enzymatic activity.
Likewise, a mixed inhibitor also occupies a site on the enzyme distinct from the active site for the substrate. A mixed inhibitor binds to the enzyme or ES complex to inhibit the reaction.
Since the binding site for uncompetitive and mixed inhibitors are distinct from the substrate-binding site on the enzyme, increasing the substrate concentration can not overcome the inhibition.
Answer:
The influx of calcium ions.
Explanation:
The influx of calcium ions at a certain point produces phase of the action potential also called depolarization which results in the ion movement changes the membrane potential from negative to positive inside the cell.
In action potential, calcium ions may control gene transcription, cell excitability, and neurotransmitter release. In chemical synapses, the influx of calcium ions leads to vesicles filled with neurotransmitters move to the surface of the cell, and into the synaptic cleft release their contents.
Answer:
C. Nucleotides
Explanation:
Nucleic acids are macromolecules which are polymers of nucleotides. There are two types of nucleic acids namely: deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). Nucleotides are the building blocks of nucleic acids.
A nucleotide is made up of three components:
- A phosphate group
- A five carbon sugar called pentose sugar. In RNA the sugar is ribose sugar and in DNA the sugar is deoxyribose sugar.
- Nitrogenous bases: There are four different types of bases in DNA: adenine, guanine, cytosine and thymine. In RNA thymine is replaced by uracil. Adenine and guanine are purines whereas cytosine, thymine and uracil are pyrimidines.
Nitrogenous base and sugar together are called nucleoside and when phosphate is also attached then it is called nucleotide.
The goal is to find out how often effective antimicrobial therapy is delayed after the start of persistent or recurrent hypotension in septic shock and how this affects mortality.
Design: A cohort research that was conducted in retrospect between July 1989 and June 2004.
Setting: Ten hospitals (four academic, six community) and fourteen critical care units (four medical, four surgical, and six combined medical/surgical) located in Canada and the United States.
Patients: The 2,731 adult patients with septic shock listed in their medical records.
Measurements and key findings: Survival to hospital discharge served as the primary outcome indicator. A survival percentage of 79.9% was found when an antibiotic efficacious for isolated or suspected infections was administered within the first hour of verified hypotension. Over the following 6 hours, each hour of antibiotic delivery delay was linked to an average 7.6% decline in survival. When compared to obtaining treatment within the first hour after the beginning of persistent or recurrent hypotension, the in-hospital mortality rate was considerably higher by the second hour (odds ratio 1.67; 95% confidence range, 1.12-2.48). The single best predictor of outcome in multivariate analysis (which included Acute Physiology and Chronic Health Evaluation II score and treatment factors) was time to the start of effective antimicrobial therapy. It took 6 hours on average to start effective antimicrobial therapy (25-75th percentile, 2.0-15.0 hrs).
Conclusions: In adult patients with septic shock, effective antibiotic therapy during the first hour of confirmed hypotension was related with enhanced survival to hospital discharge. Only 50% of patients with septic shock got efficient antimicrobial therapy within 6 hours of being diagnosed with proven hypotension, despite a steady rise in fatality rate with increasing delays.
<h3>What is
septic shock?</h3>
Septic shock is a potentially fatal illness that develops after an infection when your blood pressure drops to an unsafely low level. The infection might be brought on by any kind of bacterium.
To learn more about septic shock with the help of given link:
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