* More than 40 proteins and glycoproteins involved in the complement system are synthesized by the liver, macrophages, epithelial cells, they are present in the blood in plasmatic form, membrane, some have an enzymatic activity, regulator or membrane receptorThese are elements of the humoral innate immune response, they fight infections, purify immune complexes and apoptotic bodies.
<span>There are indeed three ways to activate the complement:</span>
Classical pathway: Activated by Immunoglobulins in immune complexes, aggregated Immunoglobulins, DNA, CRP, apoptotic bodies .......it involves nine fractions, starting with C1, then C4, C2, C3, to form a classical C5 convertase, then, activation of C5, C6, C7, C8, C9.
Alternative pathway: activated by polysaccharides (bacterial endotoxin), vascular wall poor in sialic acid, aggregated IgE ...C3b like is the first component in the alternate channel cascade, it will create an amplification loop, and form an alternative C5 convertase.
Lecithin pathway: Activated by mannose, fucose (carbohydrate of microorganisms)The first component is the complex MBL / MASP1 / MASP2: "mannose-binding protein": works according to the same principle as the complex C1 of the classical way (MASP2 cleaves the C4 and the rest of the cascade is equivalent to that of the classical way).
the three ways have the same outcome: A C5 convertase (formed by one of the pathways) cleaves C5 into C5a and C5b: C5b is deposited far from other fractions on the antigenic surface. The fixation of C5b in the cell is followed by that of C6, C7, C8, and C9 (9 molecules of C9): formation of the membrane attack complex (MAC) ==> Death of the cell by osmotic shock
1. hair
2. pore
3. oil gland
4. sweat gland
5. hair follicle
6. blood vessels
Using W=mg
12*10 m/sec squared
10 m/sec squared = 100
100*12
=
1,200 newtons
Answer:
The correct answer is the first statement.
Explanation:
A fundamental stimulus-response coupling mechanism that helps various species to react and sense different modifications taking place in various distinct environmental circumstances is known as a two-component regulatory system. Though this system is found in almost all the domains of life, however, it is generally witnessed in species like bacteria, mainly in the Gram-negative and cyanobacteria.
In case, if the response regulator turns completely phosphorylated because of the absence of phosphatase activity, the cell would become insensitive towards the environmental stimulus. This generally happens as the cell will lose its tendency to sustain the response cycle because of the imbalance in the dephosphorylation and phosphorylation system that helps in sustaining the response of the cell towards a specific environmental stimulus.
