Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.
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They both help to draw water into a plant's stem, roots, ect.
Answer: 100%
Explanation:
if the mutation presents autosomal dominant inheritance, each affected individual will show 100% alteration in the protein, thus , being dominant, it is considered that the disease pattern will predominate even if it has genes that do not express it since these will be recessive and canceled by the dominant ones.
When the capture starts to increase, the fish population
from 50 capture start to 100 capture start upsurges. At 200 capture start, though,
the population augmented in the beginning up until it touched 300 months where
it significantly dropped.
Numerous environmental factors can affect the populace of
fish. First, when there is a hurricane, the fish population will be affected
because the water will move and change.
Second, pollution. When individuals pollute the ocean, it
affects the fishes’ ability to live.
Lastly, when there is a lot of hunters that feed on fish. This
may cause many fishes to be consumed and their population will be reduced.
