Alexander the Great didn't conquer Italy. Neither did he conquer China.
Alexander the Great was the leader of the hellenistic period in Greece and contributed to the creation of one of the greatest empires at the time which was spanning all around from the Greek peninsula all the way to Mesopotamia.
Anti-Federalists were against the Constitution, so I'm fairly certain that the rest of that statement goes:
According to the Anti-Federalists, a governing document such as the Constitution should most certainly fail to protect the rights of individuals and the states.
That's the most I've got with how much you gave, I'll probably need specific choices to choose from for a more satisfying and accurate answer.
