The best and most correct answer among the choices provided by your question is the last choice.
<span>The statement "Both prokaryotic and eukaryotic cells use binary fission for asexual reproduction and mitosis for sexual reproduction." is TRUE among the eukaryotic and prokaryotic cells.</span>
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Phosphate head (hydrophilic)
Long-term potentiation (LTP) is considered a cellular correlate of learning and memory. The presence of G protein-activated inwardly rectifying K(+) (GIRK) channels near excitatory synapses on dendritic spines suggests their possible involvement in synaptic plasticity. However, whether activity-dependent regulation of channels affects excitatory synaptic plasticity is unknown. In a companion article we have reported activity-dependent regulation of GIRK channel density in cultured hippocampal neurons that requires activity oF receptors (NMDAR) and protein phosphatase-1 (PP1) and takes place within 15 min. In this study, we performed whole-cell recordings of cultured hippocampal neurons and found that NMDAR activation increases basal GIRK current and GIRK channel activation mediated by adenosine A(1) receptors, but not GABA(B) receptors. Given the similar involvement of NMDARs, adenosine receptors, and PP1 in depotentiation of LTP caused by low-frequency stimulation that immediately follows LTP-inducing high-frequency stimulation, we wondered whether NMDAR-induced increase in GIRK channel surface density and current may contribute to the molecular mechanisms underlying this specific depotentiation. Remarkably, GIRK2 null mutation or GIRK channel blockade abolishes depotentiation of LTP, demonstrating that GIRK channels are critical for depotentiation, one form of excitatory synaptic plasticity.
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Answer:
Your answer is 4. Hope this helps you. Have a great day! :)
Explanation:
Because enzymes connect to their substrate through a lock-and-key system, where the shape of the substrate and the enzyme has to fit like puzzle pieces. Then only the enzymatic reaction can occur.
