It would be "B. Bosnia" that is a real "trouble" spot, since although it is much better now, it has suffered years of violence over mostly racial and ethnic tensions.
Jim Crow laws were black codes targeted by any non-white class. They placed legal limitations on things such as voting, working, and even recreational events were limited to any non-white person.
Penicillin was so important because it was proven to reduce the amounts of deaths amputations and surgeries during world war1