The initiating event in the development of nephrotic syndrome is a derangement in the glomerular membrane that causes increased permeability to plasma proteins.
Nephrotic syndrome can be understood as a kidney disorder in which the glomeruli filter of the kidney gets damaged due to which it is unable to filter the proteins and passes an excess amount of protein in the urine.
Glomeruli filter consists of clusters of small blood vessels in the kidneys that function in filtering the waste and excess water from the blood. It also sweeps the blood protein which is necessary to maintain the correct amount of fluid in the body, from seeping into the urine. But when it gets damaged glomeruli stop sweeping the protein from the urine as a result too much blood protein leaves your body, leading to nephrotic syndrome.
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