6.Which of the following is (are) the result of insulin binding to its receptor?I. MAPK activation, which regulates gene express
ion via Fos, Jun and Myc. II. PI3K activation leading to an increase in glucose transport.III. High affinity binding of SH2 domains to phosphorylated tyrosines.IV. Autophosphorylation resulting in activation of tyrosine kinase.
- High affinity binding of SH2 domains to phosphorylated tyrosines
option lV :
- Autophosphorylation resulting in activation of tyrosine kinase.
Explanation:
The binding of SH2 domains to activated growth factor receptors like phosphorylated tyrosines controls the interaction with signaling molecules and the regulation of their activities which leads to insulin binding to the receptor.
At the cellular level, autophosphorylation process which results in activation of tyrosine kinase forms a building block for insulin binding to the receptor with the structural diversity in the mechanisms of their activation by growth factor ligands.
The Insulin receptor is a large protein that binds to insulin and passes its message into the cell. When insulin binds to the receptor, it causes a change in shape that is propagated inside the cell, which results to MAPK activation, which regulates gene expression via Fos, Jun and Myc, PI3K activation leading to an increase in glucose transport, High affinity binding of SH2 domains to phosphorylated tyrosines and Autophosphorylation resulting in activation of tyrosine kinase.
They were doctors that offered services to people affected by the plagues then. They were sent specifically to areas affected by the plagues and paid by the government themselves. They helped to keep records of victims affected by the plagues too.
