Question

6.Which of the following is (are) the result of insulin binding to its receptor?I. MAPK activation, which regulates gene expression via Fos, Jun and Myc. II. PI3K activation leading to an increase in glucose transport.III. High affinity binding of SH2 domains to phosphorylated tyrosines.IV. Autophosphorylation resulting in activation of tyrosine kinase.

Answer 1

Answer:

Option lll :

- High affinity binding of SH2 domains to phosphorylated tyrosines

option lV :

- Autophosphorylation resulting in activation of tyrosine kinase.

Explanation:

The binding of SH2 domains to activated growth factor receptors like phosphorylated tyrosines controls the interaction with signaling molecules and the regulation of their activities which leads to insulin binding to the receptor.

At the cellular level, autophosphorylation process which results in activation of tyrosine kinase forms a building block for insulin binding to the receptor with the structural diversity in the mechanisms of their activation by growth factor ligands.

Answer 2

Answer: All of the above (I, II, III, IV)

Explanation:

The Insulin receptor is a large protein that binds to insulin and passes its message into the cell. When insulin binds to the receptor, it causes a change in shape that is propagated inside the cell, which results to MAPK activation, which regulates gene expression via Fos, Jun and Myc, PI3K activation leading to an increase in glucose transport, High affinity binding of SH2 domains to phosphorylated tyrosines and Autophosphorylation resulting in activation of tyrosine kinase.