The correct answer is: "Unexpected, related or possible related to the research, suggests the research puts subjects or others at greater risk"
The OHRP defines an unticipated problem in the scenario of a research involving human participants. Defining the problem as unanticipated means that it was not foreseen at all when detailing the possible risks for the parcipants of the study on when those were asked to sign a consent form. It is also unanticipated in the sense that the problem which have aroused does not match in terms of likelihood with the characteristics of the specific individual suffering it.
Such term does not refer to some inconvenience with minimum consequences, but it suggest that the problem occurring affects the research subjects or others and places them at a greater risk of harm - physical, psychological, economic ,etc.- than was anticipated before the research.
Virginia settled was peacefully for a bit of time, then came difficult
The scenario in which Phil adopts a facial expression of frustration and says, exasperatedly, "we have to pull extra shifts since Shawn got fired." means that Phil is using the complementing function of nonverbal communication.
The complementing function of nonverbal communication ensures all speech is paralleled by non-verbal communication that aligns with the what is being said.