Jenner was found in a state of apoplexy on 25 January 1823, with his right side paralysed. He never fully recovered and eventually died of an apparent stroke, his second, on 26 January 1823, aged 73. He was buried in the Jenner family vault at the Church of St. Mary, Berkeley.He was survived by his son Robert Fitzharding (* 1797; † 1854) and his daughter Catherine (* 1794; † 1833), his elder son Edward (* 1789; † 1810) having died of tuberculosis aged 2
