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ryzh [129]
3 years ago
5

What happens to the circulatory system when someone coughs?

Biology
1 answer:
natta225 [31]3 years ago
5 0

Answer: The relationship between blood pressure and heart rate responses to coughing was investigated in 10 healthy subjects in three body positions and compared with the circulatory responses to commonly used autonomic function tests: forced breathing, standing up and the Valsalva manoeuvre. 2. We observed a concomitant intra-cough increase in supine heart rate and blood pressure and a sustained post-cough elevation of heart rate in the absence of arterial hypotension. These findings indicate that the sustained increase in heart rate in response to coughing is not caused by arterial hypotension and that these heart rate changes are not under arterial baroreflex control. 3. The maximal change in heart rate in response to coughing (28 +/- 8 beats/min) was comparable with the response to forced breathing (29 +/- 9 beats/min, P greater than 0.4), with a reasonable correlation (r = 0.67, P less than 0.05), and smaller than the change in response to standing up (41 +/- 9 beats/min, P less than 0.01) and to the Valsalva manoeuvre (39 +/- 13 beats/min, P less than 0.01). 4. Quantifying the initial heart rate response to coughing offers no advantage in measuring cardiac acceleratory capacity; standing up and the Valsalva manoeuvre are superior to coughing in evaluating arterial baroreflex cardiovascular function.

Explanation:

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If you touch a car window with no tint on a semi-sunny day and it feels warm what is most likely occurring?
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This model shows the basic process of making a protein. What are the strengths and limitations of this model?
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Answer:

Results

We systematically analyze and compare how different modelling methodologies can be used to describe translation. We define various statistically equivalent codon-based simulation algorithms and analyze the importance of the update rule in determining the steady state, an aspect often neglected. Then a novel probabilistic Boolean network (PBN) model is proposed for modelling translation, which enjoys an exact numerical solution. This solution matches those of numerical simulation from other methods and acts as a complementary tool to analytical approximations and simulations. The advantages and limitations of various codon-based models are compared, and illustrated by examples with real biological complexities such as slow codons, premature termination and feedback regulation. Our studies reveal that while different models gives broadly similiar trends in many cases, important differences also arise and can be clearly seen, in the dependence of the translation rate on different parameters. Furthermore, the update rule affects the steady state solution.

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The codon-based models are based on different levels of abstraction. Our analysis suggests that a multiple model approach to understanding translation allows one to ascertain which aspects of the conclusions are robust with respect to the choice of modelling methodology, and when (and why) important differences may arise. This approach also allows for an optimal use of analysis tools, which is especially important when additional complexities or regulatory mechanisms are included. This approach can provide a robust platform for dissecting translation, and results in an improved predictive framework for applications in systems and synthetic biology.

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2 years ago
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