Answer:
Okay
Explanation:
Human topoisomerase I plays an important role in removing positive DNA supercoils that accumulate ahead of replication forks. It also is the target for camptothecin-based anticancer drugs that act by increasing levels of topoisomerase I-mediated DNA scission. Evidence suggests that cleavage events most likely to generate permanent genomic damage are those that occur ahead of DNA tracking systems. Therefore, it is important to characterize the ability of topoisomerase I to cleave positively supercoiled DNA. Results confirm that the human enzyme maintains higher levels of cleavage with positively as opposed to negatively supercoiled substrates in the absence or presence of anticancer drugs. Enhanced drug efficacy on positively supercoiled DNA is due primarily to an increase in baseline levels of cleavage. Sites of topoisomerase I-mediated DNA cleavage do not appear to be affected by supercoil geometry. However, rates of ligation are slower with positively supercoiled substrates. Finally, intercalators enhance topoisomerase I-mediated cleavage of negatively supercoiled substrates but not positively supercoiled or linear DNA. We suggest that these compounds act by altering the perceived topological state of the double helix, making underwound DNA appear to be overwound to the enzyme, and propose that these compounds be referred to as ‘topological poisons of topoisomerase I’
Inject air into the vial with the eye of the needle immersed in the fluid.
A small needle is used to inject a substance into the tissue layer separating the skin and the muscle during a subcutaneous injection to deliver medication.
The steps involved in giving a subcutaneous injection are:
- washing hands in warm water and soap.
- assembling the necessary tools, including alcohol pads, gauze, needles, and syringes.
- examination and cleaning of the injection site.
- Putting the drug in the syringe entails:
- the vial's cap is taken off.
- air being injected into the syringe.
- inflating the virus with air.
- medicine discontinuation
- eliminating air bubbles.
- distributing the medicine.
Here is another question with an answer similar to this about subcutaneous injection: brainly.com/question/4278546
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A. It is very very wrong because another name or term for internal attribution is not situational attribution. So A is not true..
Answer:
An asymptomatic carrier
Explanation:
An asymptomatic carrier (healthy carrier or just carrier) is a person or other organism that has become infected with a pathogen, but that displays no signs or symptoms.
Although unaffected by the pathogen, carriers can transmit it to others or develop symptoms in later stages of the disease. Asymptomatic carriers play a critical role in the transmission of common infectious diseases such as typhoid, C. difficile, influenzas, and HIV. While the mechanism of disease-carrying is still unknown, researchers have made progress towards understanding how certain pathogens can remain dormant in a human for a period of time. A better understanding of asymptomatic disease carriers is crucial to the fields of medicine and public health as they work towards mitigating the spread of common infectious diseases.
