Answer:
b. Inhibiting the activity of adenylyl cyclase in the cell.
Explanation:
Cholera toxin enters the interstitial epithelial cells with the help of 5 identical B sub units and 1 A sub unit. A sub unit is catalytic and it is endocytosed in interstitial epithelial cells. Inside cells, A sub unit is cleaved into two fragments A1 and A2 with the help of proteases. A1 upon interaction with a small cytosolic G protein named as ARF-6 activates Gsα protein permanently by post translation modification known as ribosylation. This Gsα protein further acts upon an intracellular adenylate cyclase. The adenylate cyclase constitutively produces cyclic AMP (cAMP) which acts upon CFTR chloride ion channel and Na⁺ and H⁺ exchanger. As a result of this, large efflux of NaCl occurs. After NaCl loss, inside condition becomes hypotonic which leads to loss of water from the cells. This condition causes diarrhea .
But if activity of adenylate cyclase can be inhibited, the signaling cascade will come to an end leading to reduced harmful effect of cholera toxin.
Answer:
true
Explanation:
The pH scale is logarithmic and as a result, each whole pH value below 7 is ten times more acidic than the next higher value. For example, pH 4 is ten times more acidic than pH 5 and 100 times (10 times 10) more acidic than pH 6. The same holds true for pH values above 7, each of which is ten times more alkaline (another way to say basic) than the next lower whole value. For example, pH 10 is ten times more alkaline than pH 9 and 100 times (10 times 10) more alkaline than pH 8.
They are mostly made of ices.
Hope this helps!
Answer:
This is what we call Potential Energy and Kinetic Energy
Explanation:
If the bowler is rolling a ball, let's say 5 LBS, It should travel at normal speed.
The speed is also dependent on how the bowler throws the ball.
If they were to change the weight of the ball. It would most likely slow the ball down more, as it would be too heavy to go as fast if it was a lightweight ball.
It's like a person. The bigger and heavier they are, the slower they will move with their own consecutive speed. If they are lighter, they'll most likely go faster