The Avery–MacLeod–McCarty experiment<span> was an experimental demonstration, reported in 1944 by </span>Oswald Avery<span>, </span>Colin MacLeod<span>, and </span>Maclyn McCarty<span>, that </span>DNA<span> is the substance that causes </span>bacterial transformation<span>, in an era when it had been widely believed that it was </span>proteins<span> that served the function of carrying genetic information (with the very word </span>protein<span> itself coined to indicate a belief that its function was </span>primary<span>).
It was the culmination of research in the 1930s and early 20th Century at the </span>Rockefeller Institute for Medical Research<span> to purify and characterize the "transforming principle" responsible for the transformation phenomenon first described in </span>Griffith's experiment<span> of 1928: killed </span>Streptococcus pneumoniae<span> of the </span>virulent<span> strain type III-S, when injected along with living but non-virulent type II-R pneumococci, resulted in a deadly infection of type III-S pneumococci.
In their paper "</span>Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types: Induction of Transformation by a Desoxyribonucleic Acid Fraction Isolated from Pneumococcus Type III<span>", published in the February 1944 issue of the </span>Journal of Experimental Medicine<span>, Avery and his colleagues suggest that DNA, rather than protein as widely believed at the time, may be the hereditary material of bacteria, and could be analogous to </span>genes<span> and/or </span>viruses<span> in higher organisms.</span>
Answer:
DOMAIN is the broadest level of classification and ______ is the most specific.
Explanation:
I DONT KNOW THE SECOND ONE SORRY
Answer:
1. P120 is degraded in the 26S proteasome
2. The 26S proteasome has a major role in protein degradation and is critical for protein homeostasis
3. Cell cycle and DNA replication are cellular processes regulated by the Ras and NFkB pathways
Explanation:
The proliferation-associated nucleolar protein (p120) is a protein known to be expressed during the interphase of the cell cycle, specifically in G1 and early S phase, where any problem with DNA replication trigger a checkpoint, i.e., a molecular cascade of signaling events that suspend DNA replication until the problem is resolved. In mammalian cells, the 26S proteasome is responsible for catalyzing protein degradation of about 80% (or even more) of their proteins. The 26S proteasome acts to degrade rapidly misfolded and regulatory proteins involved in the cell cycle, thereby having a major role in protein homeostasis and in the control of cellular processes. It is for that reason that inhibitors that block 26S proteasome function have shown to be useful as therapeutic agents in diseases associated with the failure of protein degradation mechanisms (e.g., multiple myeloma). The NF-κB are highly conserved transcription factors capable of regulating different cellular processes including, among others, cellular growth, inflammatory responses and apoptosis. Moreover, the MAPK/ERK pathway is able to transduce different signals received on the cell surface to the nucleus. The MAPK/ERK pathway is activated when a singling molecule binds to a cell receptor which triggers a signaling cascade that ends when a transcription factor induces the expression of target genes, ultimately producing a response in the cell (for example, the progression through the cell cycle).
In some cases, massive destruction of red blood cells caused death. This drug-induced hemolytic anemia was shown 30 years later to be caused by a deficiency of glucose 6-phosphate dehydrogenase, the enzyme catalyzing the first step in the oxidative branch of the pentose phosphate pathway.
in short terms, glucose 6-phosphate dehydrogenase
