Inulin is an illustration of material of this type that cannot be reabsorbed or secreted.
How does inulin avoid being both reabsorbed and secreted?
- Due to its special characteristics, inulin is the only chemical whose clearance is precisely equal to the glomerular filtration rate (GFR).
- Although inulin is readily passed across the glomerular capillaries, neither is absorbed into the body nor released after filtering.
- As a result, the volume of inulin filtered and excreted will be the same. Because of these factors, inulin is referred to as a glomerular marker.
- The clearance ratio, which is the comparison between the clearance of any drug (x) and the clearance of inulin, is used to express this comparison. Thus,
Clearance ratio =
Therefore it can be concluded that inulin cannot be released or reabsorbed after being injected into a patient.
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