Converting Native peoples to Catholicism. This was arguably a noble venture in the minds of the colonists - by converting the Natives, they thought, they were saving their souls. Friars and Jesuits, by the way, were both orders of Catholic priests.
First obviously was his deafness. He struggled with talking to people because he could not hear what they had to say. Often he ignored others because he could not communicate that he was deaf.
Second is his love life. He did fall in love several times but because of his rank they could not be together.
In June 1812, the United States declared war against Great Britain in reaction to three issues: the British economic blockade of France, the induction of thousands of neutral American seamen into the British Royal Navy against their will, and the British support of hostile Indian tribes along the Great Lakes frontier.