The answer is the second to last and the last
I believe the correct answer would be by lowering the costs of shipped goods from the Midwest to Atlantic coast.
Hope it helps!
Slavery
The main issue of the Missouri Compromise of 1820 was how to deal with the spread of slavery into western territories. The compromise divided the lands of the Louisiana Purchase into two parts. Slavery would be allowed south of latitude 36 degrees 30'.
Natural defenses, and floods.
If you are talking about the renaissance period, patrons were extremely important for art. Patrons were usually wealthy nobles or merchants or bankers such as the Medici family for example in Florence who commissioned works of art from great artists of the time such as Rafael or Michelangelo. It is highly likely that without their wealth and their support that art of the time would not even be developed to the extent that it was.
