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Mamont248 [21]
3 years ago
7

Although the genes that cause LHON are found in cells throughout the body, LHON especially affects specific cells in the eyes an

d heart. Why do you think that tissues with these cells are among the first to fail as a result of defective mitochondria? How could a mitochondrial defect be related to vision and heart problems?Cite evidence
Biology
1 answer:
statuscvo [17]3 years ago
5 0

Answer:

Leber’s hereditary optic neuropathy (LHON) is defined as a disorder caused by a mitochondrial mutation that affects the visual and heart cells.

A  defective mitochondria is the primary cause of the LHON because it causes mtDNA is involved in the encoding of ubiquinone oxidoreductase         (subunits of NADH) that is the first complex of the electron transport chain. So, any defect or mutation in mtDNA causes neuronal defects.

<u>Mitochondrial defect due to mutation in amino acid exchanges in ubiquinone oxidoreductase affects optic nerves causing loss of retinal ganglion cells (RGCs) and their axons that leads to vison loss.</u>

<u>Mitochondrial biogenesis is the process in which mitochondrial ATP produced, and ATP transfer to heart and defect in mitochondrial biogenesis causes defect in heart cells.</u>

<u />

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