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svet-max [94.6K]
3 years ago
14

In the past 20 years, the development of NMR technology has expanded its application in the field of drugs from identification o

f chemical structures of drugs in vitro to analysis of drugs and their metabolites in body fluids and tissues. Compared with other analytical methods, what are the characteristics of NM R method?
Biology
1 answer:
Virty [35]3 years ago
3 0

Answer:

(1) the simplicity does not require complicated extraction or derivatization of the sample, thus reducing the error caused by the extraction;

(2) Non-invasive: After NMR analysis, biological samples with limited sampling volume can also be used for other treatments, and even non-invasive analysis can be carried out on the whole organism;

(3) Continuous NMR can dynamically monitor the whole biological system without disturbing all kinds of balances in the biological body and realize in-vivo analysis of drugs;

(4) The high resolution N MR spectral line is of the order of Hz, which can provide structural information at molecular level;

(5) Multi-objective can detect drugs and their metabolites under the same physical condition without groping for analysis conditions.

Explanation:

http://www.creative-biostructure.com/nmr-services_28.htm

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