Answer:
The correct answer is option - d. Production of primary spermatocytes.
Explanation:
The accessory cells or supporting cells present within the seminiferous tubules of reproductive system termed as the Sertoli cells. They play various roles in the body and reproductive system.
Sertoli cells make blood-testis barrier in adjacent Sertoli cells in the seminiferous tubules. These cells secrete different types of enzymes and hormones such as inhibin which are also secreted by ovary and placenta in females. Sertoli cells produce seminiferous tubular fluid to provide nutrition to the sperm. Apoptotic germ cells are timely eliminated by these cells.
Thus, the correct answer is option D. Production of primary spermatocytes.
Yes, it is true that Methylation of EZH2 by PRMT1 regulates its stability and promotes breast cancer metastasis.
Enhancer of zeste homolog 2 (EZH2), a key histone methyltransferase and EMT inducer, is overexpressed in diverse carcinomas, including breast cancer.
However, the molecular mechanisms of EZH2 dysregulation in cancers are still largely unknown. Here, we discover that EZH2 is asymmetrically dimethylated at R342 (meR342-EZH2) by PRMT1.
meR342-EZH2 was found to inhibit the CDK1-mediated phosphorylation of EZH2 at T345 and T487, thereby attenuating EZH2 ubiquitylation mediated by the E3 ligase TRAF6.
We also demonstrate that meR342-EZH2 resulted in a decrease in EZH2 target gene expression, but an increase in breast cancer cell EMT, invasion and metastasis.
Moreover, we confirm the positive correlations among PRMT1, meR342-EZH2 and EZH2 expression in the breast cancer tissues. Finally, we report that high expression levels of meR342-EZH2 predict a poor clinical outcome in breast cancer patients.
Our findings may provide a novel diagnostic target and promising therapeutic target for breast cancer metastasis.
Learn more about breast cancer here : brainly.com/question/6747562
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Answer:
ER → ER-to-Golgi transport vesicles → Golgi cisternae → secretory or transport vesicles →cell surface (exocytosis) (see Figure 17-13). Small transport vesicles bud off from the ER and fuse to form the cis-Golgi reticulum.
D is the answer! I just had this question and it was right !
Answer:
3 and 4
Explanation:
Both appear to be up river which mean they're coming DOWN to contaminate the uptake. If they're ahead of the uptake facility they're not going to show up in the water. I only know this because of City Skylines :)
