Answer:
Explanation:
The switch from glutamic acid to valine in position 6 of hemoglobin (HB) forms the basis of sickle cell anemia disease pathology.
Valine is hydrophobic and it's chain is shorter than glutamic acid. The lack of the carboxylic acid and shortness of valine will result in loss of the ionic interactions formed between the glutamic acid's carboxylic group and other amino acids. A hydrophobic cavity will form in the beta sheet of HB due to the short and hydrophobic structure of valine. For these reasons, the HB molecule will be less stable and insoluble in water. The insolubility is thought to be caused by fibril formation between the valine interacting with hydrophobic pocket residues of the adjacent HB molecule. This would in turn affect binding of oxygen to HB.
Answer:
Chromatin is a substance within a chromosome consisting of DNA and protein. The DNA carries the cell's genetic instructions. The major proteins in chromatin are histones, which help package the DNA in a compact form that fits in the cell nucleus. Changes in chromatin structure are associated with DNA replication and gene expression.
Explanation:
Answer:
Decomposition
Explanation:
According to the carbon cycle when organisms die they decompose and release carbon.
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Answer:
Option B You are on part of Earth that is in the umbra of the moon’s shadow
Explanation:
Solar eclipses are observable in the shadow zone created by the Moon's occultation of the Sun. In the case of a total eclipse and only in this one, the shadow zone where it is possible to observe this phenomenon of total eclipse is called “path of totality“.
