Mutations are changes in nucleotide sequence. Some are neutral because whatever amino acid substitutions they cause do not serio
usly affect the final protein. A frameshift mutation, however, can change a protein's function. To what does the frame and frameshift refer? Is it A: to a shift from the DNA framework to the RNA framework, or is it B: a shift in nucleotide groupings?
The correct answer is B: a shift in nucleotide groupings
Explanation:
Frameshift mutation is caused by the addition or deletion of base pairs in the protein-coding regions of DNA during replication. Nucleotides are arranged in a group of three which are called codons that code for a particular amino acid during protein formation.
This translational reading frame of codon disrupts when any nucleotide gets added in the reading frame or gets subtracted from it because it cause the shifting of the translational reading frame.
This shift in nucleotide group can lead to the formation of inactive protein or functionally changed protein. Therefore the correct answer is B.
