The main way in which advances in learning and technology influenced 15th and 16th century european exploration and trade is that the Renaissance Era in Europe brought back an interest in exploration of all kinds--from the sciences to the arts--meaning that people were interested in discovering known things and "worlds".
Answer:
This is the answer of your question.
Answer:
It became legal for farmers to transport hemp across state lines.
Explanation:
I believe the answer is smallpox, but I could be mistaken. There were lots of viruses threatening the population at the time but from what I know, smallpox was the largest threat.