Answer:
Hepato- and nephrotoxicity of fluoride have been demonstrated in animals, but few studies have examined potential effects in humans. This population-based study examines the relationship between chronic low-level fluoride exposure and kidney and liver function among United States (U.S.) adolescents. This study aimed to evaluate whether greater fluoride exposure is associated with altered kidney and liver parameters among U.S. youth.
This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (2013–2016). We analyzed data from 1983 and 1742 adolescents who had plasma and water fluoride measures respectively and did not have kidney disease. Fluoride was measured in plasma and household tap water. Kidney parameters included estimated glomerular filtration rate (calculated by the original Schwartz formula), serum uric acid, and the urinary albumin to creatinine ratio. Liver parameters were assessed in serum and included alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, blood urea nitrogen, gamma-glutamyl transferase, and albumin. Survey-weighted linear regression examined relationships between fluoride exposure and kidney and liver parameters after covariate adjustment. A Holm-Bonferroni correction accounted for multiple comparisons.
The average age of adolescents was 15.4 years. Median water and plasma fluoride concentrations were 0.48 mg/L and 0.33 μmol/L respectively. A 1 μmol/L increase in plasma fluoride was associated with a 10.36 mL/min/1.73 m2 lower estimated glomerular filtration rate (95% CI: −17.50, −3.22; p = 0.05), a 0.29 mg/dL higher serum uric acid concentration (95% CI: 0.09, 0.50; p = 0.05), and a 1.29 mg/dL lower blood urea nitrogen concentration (95%CI: −1.87, −0.70; p < 0.001). A 1 mg/L increase in water fluoride was associated with a 0.93 mg/dL lower blood urea nitrogen concentration (95% CI: −1.44, −0.42; p = 0.007).
Fluoride exposure may contribute to complex changes in kidney and liver related parameters among U.S. adolescents. As the study is cross-sectional, reverse causality cannot be ruled out; therefore, altered kidney and/or liver function may impact bodily fluoride absorption and metabolic processes.
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Answer:
The post-transcriptional modifications in the mRNA produced as a result of the transcription in eukaryotes provide many advantages to the mRNA.
The two post-transcriptional modifications are the addition of 7-methylguanosine cap at 5' end of mRNA called capping whereas the addition of the poly(Adenyl) tail at 3' end called tailing.
The advantages of capping are:
1. Protection of nascent mRNA from the degradation.
2. Recognition by transcription factors helps in translation.
The advantages of tailing are:
1. Protection of the mRNA from enzymatic degradation in the cytosol.
2. Transcription termination
3. Export of the mRNA from the nucleus
Answer:
b. "C" “B” “A,” “D”
Explanation:
C is prophase because the nuclear envelope starts to disappear and the centrosomes divide
B is metaphase because chromosomes line up to form the equatorial plate
A is anaphase because the sister chromatids are separated
D is telophase because new nuclei form around the separated genetic material
The walls of xylem cells are lignified (strengthened with a substance called lignin ). This allows the xylem to withstand pressure changes as water moves through the plant.
The cell membrane is flexible because of the presence of oil like substances called phospholipids, which gives it a fluid nature. While as the cell walls are rigid because of the presence of the thick layers of the substances like cellulose in plants, chitin in fungi and peptidoglycon in bacteria.
Answer:
The correct answer is - economic, social, environmental, and geopolitical
Explanation:
Natural Resources are the resources that are formed in nature on their own and can be renewable or non-renewable. There are various risks and benefits are associated with the production of all forms of energy other resource extraction.
These costs or risk includes economic, environmental, social, and geopolitical risks. These risks have various factors that decide if these risk or benefit and can be altered by the new technologies using for the extraction and production of various forms of energy.
