The enzyme produced by the TYR gene, called tyrosinase<span>, is required for the synthesis of </span>melanin<span> pigment. A mutation in the TYR gene causes the most common form of albinism.</span>
You know Melanin is produced by cells called melanocytes, which are found in your skin and eyes. A mutation can have as conquence to don't produce melanin that your eyes need.
In shot, the answer would be : a mutation in the TYR gene.